ABC
Prebiotic | Live Probiotic | Peptide*
BENEFITS
- Supports Healthy Gut Microbiota
- Aids in Optimizing Gut Barrier Integrity
- Helps Promote GLP-1 Production
- Promotes Leaner Body Composition
Humans Requiring
-
Comprehensive Digestive Support
-
Metabolic, Specifically GLP-1, Support
-
Gut-Brain Axis Maintenance
-
Intestinal Permeability Support
Active Ingredients: Akkermansia (Live Akkermansia muciniphila), Body Protective Compound 250mcg (as BPC-157 Arginate Salt), Sunfiber® Prebiotic (Galactomannan Fiber), Salcaprozate Sodium (SNAC)
Other Ingredients: Vegetable Capsule (Hypromellose, Gellan Gum), Microcrystalline Cellulose, Magnesium Stearate
HOW TO USE (HUMANS)
PREBIOTIC | LIVE PROBIOTIC | PEPTIDE*
OVERVIEW
ABC (Akkermansia-BPC-Complex) provides a new approach to cellular longevity via gut health and metabolic optimization. Informed by the latest research on microbiome profiles in Centenarians. this "first-of-it's-kind" formulation is at the cutting edge of longevity science. Two primary areas emerge from the data as being critical for longevity: gut barrier integrity and metabolic function, especially as it relates to GLP-1. ABC is designed specifically to harness the synergistic power of Akkermansia, BPC-157, and Sunfiber® to support metabolic optimization and microbiome profiles found amongst blue zone Centenarians.
INGREDIENTS
AKKERMANSIA & BPC-157 BASICS
First. it is important to understand the biochemical role Akkermansia muciniphila plays in the gut as it relates to metabolic health. It all comes down to its interactions with glucagon-like peptide-1 (GLP-1), an important hormone produced by the intestinal cells, which plays a vital role in regulating glucose metabolism and insulin secretion. Akkermansia muciniphila
is known to increase the production and secretion of GLP-1 in the intestine by utilizing mucin, a glycoprotein present in the mucus lining of the gut. as its primary source of energy.1 During the process of mucin degradation, Akkermansia releases metabolites that stimulate the intestinal L-cells to secrete more GLP-1.2 The increased levels of GLP-1 then act on various tissues, such as the pancreas, liver, and muscles, to promote better glucose control, support insulin sensitivity, and regulate appetite. ultimately contributing to improved metabolic health.3
BPC-157, on the other hand, plays an important supporting role via its effects on gut tissue and barrier integrity. This peptide is responsible for maintaining and continuously supporting the intestinal architecture. which allows the myriad of chemical interactions to occur without interrupt ion within the gut ecosystem.
BPC-157 / AKKERMANSIA SYNERGY
Because the biochemical relationship between Akkermansia and the intestinal barrier is heavily dependent on a high level of structural integrity within the gut lining, BPC-157 serves as the ideal companion. As BPC-157 plays a vital role in rejuvenating and maintaining gut tissues, supporting barrier function, it creates the optimaI environment for Akkermansia's broad biochemical function.
Additionally, Sunfiber serves as a rich prebiotic source for short-chain fatty acid production, in particular butyrate. As a trio. they all work in harmony to support a healthy gut microbiome, improve nutrient absorption and optimize metabolic function. This synergistic interaction lays the foundation for longevity by fostering a resilient gut environment that contributes to overall healthspan and vitality.
SERVING SIZE: 1 CAPSULE | 60 SERVINGS PER CONTAINER
INGREDIENTS |
AMOUNT PER SERVING
|
Akkermansia (Live Akkermansia muciniphila) |
500 Million AFU
|
Body Protective Compound 250mcg (as BPC-157 Arginate Salt) |
250mcg
|
Sunfiber® Prebiotic (Galactomannan Fiber) |
250mg
|
Salcaprozate Sodium (SNAC) |
1.5mg
|
Other Ingredients: Vegetable Capsule
(Hypromellose, Gellan Gum), Microcrystalline Cellulose, Magnesium Stearate
Please note: I do not currently recomend this new supplement, which is made for humans only, to be given to dogs or cats. I am, frankly, somewhat concerned about the safety of Salcaprozate Sodium (SNAC), considered one of the most advanced intestinal permeation enhancers (PEs) that has been tested in clinical trials for oral delivery of macromolecules. It's effect on intestinal epithelia has been studied for over 30 years, yet there is still debate over the mechanisms of action. While SNAC has generally regarded as safe (GRAS) status and is Food and Drug Administration (FDA)-approved as a medical food, it's use in dogs and cats has not been investigated or tested at all. Additionally, the question arises as to whether PEs can cause irreversible epithelial damage and tight junction openings sufficient to permit co-absorption of payloads with bystander pathogens, lipopolysaccharides, or exo/endotoxins that may be associated with sepsis, inflammation and autoimmune conditions. Most PEs seem to cause membrane perturbation to varying extents that is rapidly reversible, and overall evidence of pathogen co-absorption is generally lacking. It is unknown however, whether the intestinal epithelial damage-repair cycle is sustained during repeat-dosing regimens for chronic therapy. This is why I purchased the BPC-157 capsules that does not contain this PE ingredient.